Publications

“Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation”
Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L M Lamfers, Ann M Hopkins, Markus Rehm, Brona M Murphy
Cell Death Dis. 2021 Aug 3;12(8):763.

* https://www.nature.com/articles/s41419-021-04050-7


“Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell cultures”
Cassandra Verheul, Ioannis Ntafoulis, Trisha V Kers, Youri Hoogstrate, Pier G Mastroberardino, Sander Barnhoorn, César Payán-Gómez, Romain Tching Chi Yen, Eduard A Struys, Stijn L W Koolen, Clemens M F Dirven, Sieger Leenstra, Pim J French, Martine L M Lamfers
Neurooncol Adv. 2021 Aug 2;3(1):vdab103
* https://academic.oup.com/noa/article/3/1/vdab103/6335076


“The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: Phenotypic selection can occur with and without a downshift in promoter methylation status”
Ayoub Lasri and Marc Sturrock
J Theor Biol. 2021 Jul 21;521:110662
* https://www.sciencedirect.com/science/article/pii/S0022519321000849?via%...


“Chapter 9 - Role of multidrug resistance in glioblastoma chemoresistance: Focus on ABC transporters”
Mohammed Ahmed, Maite Verreault, Xavier Declèves, Ahmed Idbaih
In Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies, Volume 15 in Cancer Sensitizing Agents for Chemotherapy. 2021, Pages 243-261.


“Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist”
Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L M Lamfers, Brona M Murphy, Markus Rehm
Cell Death Dis. 2021 Jun 24;12(7):647
* https://www.nature.com/articles/s41419-021-03927-x


“Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors”
Anaïs Oudin, Virginie Baus, Vanessa Barthelemy, Carina Fabian, Eliane Klein, Monika Dieterle, May Wantz, Ann-Christin Hau, Claire Dording, Amandine Bernard, Alessandro Michelucci, Yahaya A. Yabo, Georgia Kanli, Olivier Keunen, Rolf Bjerkvig, Simone P. Niclou, and Anna Golebiewska
STAR Protocols. 2021 June 18;2(2): 100534
* https://star-protocols.cell.com/protocols/657


“IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme”
Manasa Kalya, Alexander Kel, Darius Wlochowitz, Edgar Wingender, Tim Beißbarth
Front Genet. 2021 Jun 15;12:670240.

* https://www.frontiersin.org/articles/10.3389/fgene.2021.670240/full


“Master regulators associated with poor prognosis in glioblastoma”
Kalya MP, Beisbarth T, Kel A
Biomed Khim [Russian]. 2021 May;67(3):201-212.
* http://pbmc.ibmc.msk.ru/en/article-en/PBMC-2021-67-3-201/


“Transcriptional CDK inhibitors CYC065 and THZ1 Induce apoptosis in glioma stem cells derived from recurrent GBM”
Viktorija Juric, Heiko Düssmann, Martine L.M. Lamfers, Jochen H.M. Prehn, Markus Rehm, Brona M. Murphy
Cells. 2021 May;10(5), 1182
* https://www.mdpi.com/2073-4409/10/5/1182/htm


“Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization”
Ana Rita Pombo Antunes, Isabelle Scheyltjens, Francesca Lodi….Frederik De Smet, Diether Lambrechts, Jo A. Van Ginderachter & Kiavash Movahedi
Nat Neurosci. 2021 Apr;24(4):595-610
* https://www.nature.com/articles/s41593-020-00789-y


“The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: Phenotypic selection can occur with and without a downshift in promoter methylation status”
Ayoub Lasri and Marc Sturrock 
J Theor Biol. 2021 Mar 6;521:110662
* https://www.sciencedirect.com/science/article/pii/S0022519321000849?via%...


“Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies”
Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons and Annette T. Byrne.
Cancers 2020, 12(12), 3531;
* https://www.mdpi.com/2072-6694/12/12/3531


“Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology”
Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A Yabo, Virginie Baus, Vanessa Barthelemy, Eliane Klein, Sébastien Bougnaud, Olivier Keunen, May Wantz, Alessandro Michelucci, Virginie Neirinckx, Arnaud Muller, Tony Kaoma, Petr V Nazarov, Francisco Azuaje, Alfonso De Falco, Ben Flies, Lorraine Richart, Suresh Poovathingal, Thais Arns, Kamil Grzyb, Andreas Mock, Christel Herold-Mende, Anne Steino, Dennis Brown, Patrick May, Hrvoje Miletic, Tathiane M Malta, Houtan Noushmehr, Yong-Jun Kwon, Winnie Jahn, Barbara Klink, Georgette Tanner, Lucy F Stead, Michel Mittelbronn, Alexander Skupin, Frank Hertel, Rolf Bjerkvig, Simone P Niclou.
Acta Neuropathol. 2020 Oct 3. doi: 10.1007/s00401-020-02226-7
* https://link.springer.com/article/10.1007/s00401-020-02226-7


 “New hints towards a precision medicine strategy for IDH wild-type glioblastoma”
Kieron White, Kate Connor, James Clerkin, Brona M Murphy, Manuela Salvucci, Alice C O'Farrell, Markus Rehm, David O'Brien, Jochen H M Prehn, Simone P Niclou, Martine L M Lamfers, Maite Verreault, Ahmed Idbaih, Roel Verhaak, Anna Golebiewska, Annette T Byrne
Ann Oncol. 2020 Sep 9:S0923-7534(20)42428-7. doi: 10.1016/j.annonc.2020.08.2336
* https://www.annalsofoncology.org/article/S0923-7534(20)42428-7/fulltext


“Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics”
Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy and Marc Sturrock
R Soc Open Sci. 2020 Jul 8;7(7):191243. doi: 10.1098/rsos.191243.
* https://royalsocietypublishing.org/doi/10.1098/rsos.191243


“Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions”
Viktorija Juric & Brona M Murphy
Cancer Drug Resist 2020;3:48-62. doi: 10.20517/cdr.2019.105
* https://oaepublishstorage.blob.core.windows.net/cea2cd35-afcd-4406-8d4f-...


“Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma”
Janis J. Noonan, Monika Jarzabek, Frank A. Lincoln, Brenton L. Cavanagh, Arhona R. Pariag, Viktorija Juric, Leonie S. Young, Keith L. Ligon, Hanne Jahns, Daniella Zheleva, Jochen H. M. Prehn, Markus Rehm, Annette T. Byrne and Brona M. Murphy
Cancers (Basel). 2019 Dec 12;11(12):2005. doi: 10.3390/cancers11122005
* https://www.mdpi.com/2072-6694/11/12/2005/htm


System-based approaches as prognostic tools for glioblastoma”
Manuela Salvucci, Zaitun Zakaria, Stephen Carberry, Amanda Tivnan, Seifert V, Kögel D, Brona M Murphy, Jochen H M Prehn
BMC Cancer. 2019 Nov 12;19(1):1092. doi: 10.1186/s12885-019-6280-2.
* https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6280-2


"Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents"
Ian S. Miller, Liam P. Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M. Gallagher, Norma O' Donovan, Robert S. Kerbel, John Crown & Annette T. Byrne
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591410/


"RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells"
Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice O'Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T. Byrne and Wim E. Hennink
* https://link.springer.com/article/10.1007%2Fs13346-019-00637-y


"Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism"
Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy & Markus Rehm (Morrison)
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212537/


"Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance"
Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner & Markus Rehm (Morrison)
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864878/