Publications

“Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies”
Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons and Annette T. Byrne.
Cancers 2020, 12(12), 3531;
* https://www.mdpi.com/2072-6694/12/12/3531


“Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology”
Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A Yabo, Virginie Baus, Vanessa Barthelemy, Eliane Klein, Sébastien Bougnaud, Olivier Keunen, May Wantz, Alessandro Michelucci, Virginie Neirinckx, Arnaud Muller, Tony Kaoma, Petr V Nazarov, Francisco Azuaje, Alfonso De Falco, Ben Flies, Lorraine Richart, Suresh Poovathingal, Thais Arns, Kamil Grzyb, Andreas Mock, Christel Herold-Mende, Anne Steino, Dennis Brown, Patrick May, Hrvoje Miletic, Tathiane M Malta, Houtan Noushmehr, Yong-Jun Kwon, Winnie Jahn, Barbara Klink, Georgette Tanner, Lucy F Stead, Michel Mittelbronn, Alexander Skupin, Frank Hertel, Rolf Bjerkvig, Simone P Niclou.
Acta Neuropathol. 2020 Oct 3. doi: 10.1007/s00401-020-02226-7
* https://link.springer.com/article/10.1007/s00401-020-02226-7


 “New hints towards a precision medicine strategy for IDH wild-type glioblastoma”
Kieron White, Kate Connor, James Clerkin, Brona M Murphy, Manuela Salvucci, Alice C O'Farrell, Markus Rehm, David O'Brien, Jochen H M Prehn, Simone P Niclou, Martine L M Lamfers, Maite Verreault, Ahmed Idbaih, Roel Verhaak, Anna Golebiewska, Annette T Byrne
Ann Oncol. 2020 Sep 9:S0923-7534(20)42428-7. doi: 10.1016/j.annonc.2020.08.2336
* https://www.annalsofoncology.org/article/S0923-7534(20)42428-7/fulltext


“Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics”
Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy and Marc Sturrock
R Soc Open Sci. 2020 Jul 8;7(7):191243. doi: 10.1098/rsos.191243.
* https://royalsocietypublishing.org/doi/10.1098/rsos.191243


“Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions”
Viktorija Juric & Brona M Murphy
Cancer Drug Resist 2020;3:48-62. doi: 10.20517/cdr.2019.105
* https://oaepublishstorage.blob.core.windows.net/cea2cd35-afcd-4406-8d4f-...


“Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma”
Janis J. Noonan, Monika Jarzabek, Frank A. Lincoln, Brenton L. Cavanagh, Arhona R. Pariag, Viktorija Juric, Leonie S. Young, Keith L. Ligon, Hanne Jahns, Daniella Zheleva, Jochen H. M. Prehn, Markus Rehm, Annette T. Byrne and Brona M. Murphy
Cancers (Basel). 2019 Dec 12;11(12):2005. doi: 10.3390/cancers11122005
* https://www.mdpi.com/2072-6694/11/12/2005/htm


System-based approaches as prognostic tools for glioblastoma”
Manuela Salvucci, Zaitun Zakaria, Stephen Carberry, Amanda Tivnan, Seifert V, Kögel D, Brona M Murphy, Jochen H M Prehn
BMC Cancer. 2019 Nov 12;19(1):1092. doi: 10.1186/s12885-019-6280-2.
* https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6280-2


"Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents"
Ian S. Miller, Liam P. Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M. Gallagher, Norma O' Donovan, Robert S. Kerbel, John Crown & Annette T. Byrne
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591410/


"RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells"
Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice O'Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T. Byrne and Wim E. Hennink
* https://link.springer.com/article/10.1007%2Fs13346-019-00637-y


"Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism"
Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy & Markus Rehm (Morrison)
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212537/


"Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance"
Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner & Markus Rehm (Morrison)
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864878/